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Home Learn CBD for Inflammation and Pain Relief—The How, the Why, and the Science


CBD for Inflammation and Pain Relief—The How, the Why, and the Science

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Scientists are starting to believe that inflammation is the root of all disease. By reducing inflammation, it appears possible to treat every known condition even if the pathogenesis of many diseases remains complex.

In recent years, the medical science community has looked at a variety of plant-based compounds that have potential antioxidant properties. Among these compounds are the non-intoxicating cannabinoids, such as CBD, CBG, and CBN. Each of these fascinating substances has caught the eye of the international pharmaceutical industry, and efforts are underway to make CBD and other cannabinoids mainstream medical treatments.

Fully repeatable and dependable CBD is now available from non-hemp sources, taking the fight against inflammation to an entirely new level. Learn about the connection between CBD and inflammation and how using natural antioxidants could bring your body into a lasting balance.

What is chronic inflammation, and why does it cause pain?

Inflammation is part of a natural immune response. When you are physically injured, your immune system inflames the hurt area to heal it. This type of inflammation is called acute inflammation, and it is a normal, healthy function of your immunity.

In some cases, however, inflammation can be perpetuated with no clear and present need. Arthritis is an obvious example of an overactive immune response leading to painful chronic inflammation that gradually degrades your joints. As you can see, inflammation can be either helpful or harmful.

When chronic inflammation gets out of control, it eats away at your tissues, which sends pain signals through your nervous system. Over time, conditions that cause chronic inflammation can degrade even the toughest bodily tissues and cause excruciating pain.

What does CBD do in the body?

CBD does not work the same way as THC. While THC mainly affects the CB1 and CB2 receptors, causing a feeling of intoxication, CBD exerts a much subtler effect on the body and nervous system. This cannabinoid operates within channels that are already familiar to medical science, but researchers have often found themselves astonished when confronted with the sheer therapeutic potential that non-intoxicating cannabinoids like CBD have to offer.

Along with the other cannabinoids that don’t get you high, CBD appears to significantly modulate the functioning of your immune system, which could have an impact on chronic inflammation. The international CBD industry is still too new to provide any clear data on the usefulness of cannabidiol for pain and inflammation, and major regulatory institutions have yet to rule on the status of this cannabinoid.

Regardless, there’s a lot of information to share on CBD for brain inflammation and other inflammatory conditions. To make the best purchasing decisions, take your time to absorb all the following data.

Does CBD help with pain?

Does CBD oil help with inflammation and other painful conditions? For years, the most commonly repeated claim regarding CBD is that it helps with pain. We aren’t in the business of making unsubstantiated medical claims, but that doesn’t mean we haven’t followed every development in the CBD industry with extreme interest.

The global regulatory status of CBD remains in flux, but that hasn’t stopped millions of people from taking their health in their own hands with this non-intoxicating cannabinoid. Now that CBD is available from sources other than hemp, we’re finally approaching the perfected form of the international cannabinoid industry.

With repeatable material and reduced regulatory hurdles, research into CBD for pain and inflammation will continue to accumulate at an unprecedentedly rapid rate. In the meantime, here’s what you should know about the research that’s been conducted on this subject so far:

CBD as a 5-HT1A modulator

After receiving anecdotal reports regarding the potential usefulness of CBD oil for pain, the first thing that cannabis researchers did was try to isolate the mechanisms of action that would theoretically allow this effect to occur. A mechanism of action is the way that a particular substance operates in your body, and figuring out exactly how drugs and supplements work has long been a key focus of medical science and research.

Early on, researchers started to suspect that CBD interacts with the serotonergic system, which is involved in hundreds of critical bodily processes from metabolism to neurochemistry. Most importantly, the serotonergic system is critically involved in managing neuropathic pain. If it’s true that CBD modulates how your nervous system uses serotonin, we’re one step closer to understanding just how this simple substance has received such heartfelt international acclaim.

Agonistic properties of cannabidiol at 5-HT1a receptors.

In this review of the available evidence, researchers discuss the possibility that CBD acts as an agonist at the 5-HT1A receptors. An agonist is a substance that activates a neuroreceptor, and in this case, some researchers think that CBD might activate the neuroreceptor 5-HT1A, which is the largest and most important component of the serotonergic system. The authors conclude that “CBD is a modest affinity agonist at the human 5-HT1a receptor” based on the evidence laid out in the studies they reviewed.

Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors

This highly thorough study took a look at the impact of CBD on both the 5-HT1A and glutamate receptors. In conclusion, the authors found that the evidence they’d accumulated indicated that CBD enhances “serotonergic and glutamate cortical signalling through a 5-HT1A receptor-dependent mechanism.”

CBD as a TRPV1 modulator

While the serotonergic system controls neuropathic pain, the TRPV1 receptor is most responsible for regulating inflammatory pain, which is the other main category of pain people experience. If CBD interacts with both TRPV1 and the serotonergic system, it’s natural that both consumers and corporations have been extremely keen to learn more about this non-intoxicating cannabinoid. Here are the key results:

Cannabinoid Ligands Targeting TRP Channels

This highly technical, comprehensive overview of the interaction between cannabinoids and the TRP receptors concludes that a “broad range of cannabinoids (endogenous, phytogenic, and synthetic cannabinoids) act at one or more of the following ionotropic channels: TRPV1, TRPV2, TRPV3, TRPV4, TRPA1 and TRPM.” The authors also report that, while not having significant interaction with the CB1 or CB2 receptors, CBD is “reported to be most potent at TRPV1 and TRPM8 channels.”

Cannabinoids and Pain: New Insights From Old Molecules

In this wide-ranging review of the available evidence, the authors discuss the relationship between CBD and the TRP receptors in great detail. In addition to minor interactions with conventional cannabinoid receptors, the authors relate that CBD also appears to affect the “activity of a significant number of other targets, including non-cannabinoid GPCRs (e.g., 5-HT1A), ion channels (TRPV1, TRPA1 and TPRM8, GlyR).”

Why are CBD patches good for pain?

If CBD is useful for pain, it makes sense to determine the most effective methods available for delivering this non-intoxicating cannabinoid into your system. First, it’s important to source the best possible forms of CBD, and the international medical science community has agreed for decades that synthesised cannabinoids are the direction the industry is inevitably taking.

Why? Synthesised substances are always more reliable and easier to produce than their natural counterparts. Once reliable, synthesised CBD sourcing is taken care of, the only remaining step is determining the best possible way to ingest this non-intoxicating cannabinoid.

Transdermal patches have better bioavailability than substances you take orally. Bioavailability is the measurement of how much of a substance your body can use before it is excreted, so you want the bioavailability of any beneficial substance you take to be as high as possible. The delayed-release mechanism offered by transdermal patches may also be a better approach to treating pain than the release of a large CBD dosage for inflammation separated by the span of multiple hours.

Try a new approach to pain with CPatch CBX

Due to an ever-increasing flow of investment and public interest, the international CBD industry continues to evolve at a rapid pace. Big names in the pharmaceutical industry have anticipated the advent of non-hemp cannabinoids for years now, but these special interests clearly intended to have total control of the synthesised cannabinoid sphere once it emerged.

To the benefit of everyone in the world, however, independent entrepreneurs cracked the non-hemp cannabinoid code first, and CBD from sources other than hemp is now available throughout the UK and EU with CPatch CBX. Synthesised cannabinoids offer better purity and reliability, and as we’ve covered above, transdermal patches are much more effective than other ingestion methods commonly used with CBD.

The hemp CBD industry can be disappointing, but we’re here with the next step. With CPatch CBX, you can explore all the pain-fighting potential of CBD without worrying about variations between batches or the presence of agricultural toxins. Take an advanced approach to your pain and inflammation by trying CPatch CBX today.

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About the author
Katie Hipwell - Katie is an AfN Registered Nutritionist (RNutr) with a specialism in food and is Head of Nutrition at Feel. Katie has worked in the food supplement industry for 10 years. She has completed a Master's degree in Human Nutrition and an undergraduate degree in BSc Sport and Exercise Nutrition.
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